Manufacturing Associate

at Company: Acambis, Inc. in Job Category: Manufacturing
posted on 7/22/08 12:00am

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Company
Acambis, Inc.

Contact Name:
Human Resources

Email:
careers@acambis.com

Job Reference Code:
08-031

Acambis is a leading vaccine company developing novel vaccines that address significant unmet medical needs or substantially improve standards of care. ChimeriVax(TM)-JE, Acambis' most advanced product in its development-stage pipeline, has to date shown an excellent safety and efficacy profile following pivotal Phase 3 trials. It is currently undergoing paediatric trials in the endemic region and is partnered with Sanofi Pasteur. Acambis' proprietary ChimeriVax(TM) technology, developed in association with St Louis University, has also been used to develop ChimeriVax(TM)-West Nile, which is undergoing Phase 2 clinical testing, making it the most advanced investigational vaccine against the West Nile virus. Acambis has established a global collaboration with Sanofi Pasteur for further development and commercialisation of the vaccine. ChimeriVax(TM) has also been applied to development of Sanofi Pasteur's tetravalent dengue vaccine, which has successfully demonstrated proof-of-concept in a Phase 2 trial by generating 100% seroconversion to all four dengue virus serotypes.

Acambis' ACAM-CDIFF(TM) is the only vaccine in development against Clostridium difficile bacteria, a leading cause of hospital-acquired infections. C. difficile is estimated to cause at least 360,000 cases of C. difficile-associated disease in the US alone, and annual costs to US and European healthcare systems are estimated to be in excess of $7bn a year. Acambis' influenza programme aims to develop a universal vaccine against influenza, for which a universal 'A' strain vaccine, ACAM-FLU-A(TM), was recently tested in a Phase 1 trial and pre-clinical challenge study. Acambis is currently undertaking pre-clinical testing of a vaccine candidate, dl5-29, against genital herpes.

Acambis is recognised internationally as the leading producer of smallpox vaccines for emergency-use stockpiles held by the US Government and several other governments around the world. Acambis developed its ACAM2000(TM) smallpox vaccine under contracts with the US Government.

Acambis is based in Cambridge, UK and Cambridge, Massachusetts, US, and is listed on the London Stock Exchange (ACM). More information is available at www.acambis.com

Our Canton office is currently looking for a Manufacturing Associate to perform upstream and downstream production activities in a cGMP manufacturing environment.

Job Responsibilities:
• Perform Upstream and Downstream processing using one or more of the following unit-processing steps:
o Bioreactor Operations
o Tangential Flow Filtration
o Depth Filtration
o Media Preparation and filtration
• Operate Clean-in-Place (CIP) and Steam-in-place (SIP) Systems
• Perform Mammalian cell culture and sampling operations using aseptic technique
• Operate general production equipment such as Autoclaves, Incubators, pH/Conductivity meters
• Document and maintain production activity records according to cGMP regulations
• Perform other duties as assigned


The right individual needs an Associate or a Bachelors degree in a scientific discipline with a minimum of 2 years' related experience and demonstrated working knowledge of scientific principles. Must be able to read and follow detailed instructions and have good written and verbal communication skills as well as interpersonal skills to work in a team environment. This position requires Immunization prior to performing work within the manufacturing area. Flexibility to work according to the production schedule is necessary; may require weekend, holiday and overtime work.


CONTACT INFO:

Human Resources
Acambis Inc.
38 Sidney Street
Cambridge, MA 02139
E-mail: careers@acambis.com
Interested applicants must apply on-line attaching a word document to your email submission

Acambis Inc. provides a competitive salary and a full range of benefits.

We are proud to be an equal opportunity employer, dedicated to promoting a culturally diverse workplace.

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